Assoc. Prof. QUAN LE HA

Lecturer, Director 2013-2018

Office: 208-C4

Phone: +84-24 3868 2453

Fax: +84-24 3868 2470

Email: ha.quanle@hust.edu.vn

Qualifications

  • 1990: Engineer, Fermentation technology, Voronezh University of Technology, Russia
  • 1993: Master, Fermentation technology, Hanoi University of Science and Technology (formerly Hanoi University of Technology), Vietnam
  • 1996-1997: Training course in biotechnology Swiss Federal Institute of Technology, Laussanne, Switzeland
  • 2000: PhD, Food biotechnology, Hanoi University of Science and Technology (formerly Hanoi University of Technology), Vietnam
  • 2001: Training course in biotechnology, Department of Industrial Biotechnology, Gembloux Agricultural Unversity , Belgium
  • 2005: Training course in biotechnology, Royal Melbourne Institute of Technology (RMIT), Australia
  • 2010: Associate professor of Food Technology

Professional experience

  • 12/2013-11/2018: Director, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam.
  • 2008-2013: Vice Director, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam
  • 2006-2008: Head of department of Biotechnology, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam
  • 2004-2006: Deputy Head of department of Biotechnology, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam
  • 1991-1993: Assistant lecturer, Center for biotechnology, Hanoi University of Science and Technology, Vietnam.
  • 1993-present: Lecturer, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam.

Research interests

  • Microbial technology
  • Technology of fermented beverages
  • Enzymatic hydrolysis of protein sources for making bioactive peptides
  • Biological control agent for storages of fruits
  • Anti-alpha- glucosidase from microorganism

Teaching responsibilities

  • BF2701:  Introduction to biotechnology
  • BF3708: Analytical methods in biotechnology
  • BF4175: Microbial biomass technology
  • BF5712: Amino-acid technology
  • BF6113: Downstream process
  • BF7051: Application of biotechnological techniques in industry

Publications

Books

  • Tien-Thanh Nguyen, Phu-Ha Ho, Viet-Phu Tu, Le-Ha Quan and Son Chu-Ky, 2019. Chapter 12.1. Application and Perspectives in Different World Regions. Part 12.MARKET TRENDS, PROSPECTIVES, SUSTAINABLE DEVELOPMENT, AND R&D PERSPECTIVES. Gases in Agro-food Processes. Elsevier, Academic Press, pp: 31-35, ISBN: 9780128124659.
  • Ngo Dinh Binh, Le Thanh Hoa, Tang Thi Chinh, Le Nhu Kieu, Quan Le Ha, Nguyen Duc Hoang, Le Trong Tai. Microbial technology. Current status, potentials and development trends in Vietnam. Labor publishing house, 2020.
  • Nguyen Thi Hien, Le Gia Hy, Quan Le Ha, Tu Viet Phu. Technology of Enzyme, protein production and application. Vietnam Education publisher, 2012.
  • Quan Le Ha, Nguyen Thi Hien. Amino-acid production and application. Vietnam Education publisher, 2011.
  • Le Van Nhuong, Nguyen Van Cach, Quan Le Ha, Tran Lien Ha, Nguyen Thanh Hang, Hoang Dinh Hoa, Nguyen Lan Huong, Ngo Thi Mai, Dinh Kim Nhung, Khuat Huu Thanh, Nguyen Quang Thao, Pham Thi Thuy, Pham Van Toan. Basics of Biotechnology. 4th Volume: Microbial technology. Vietnam Education publisher, 2009.
  • Le Van Tan, Nguyen Thi Hien, Hoang Thi Le Hang, Quan Le Ha. Technology for preserving and processing vegetables and fruits. Science and Techniques Publishing house, 2008.

Articles (recent 5 years)

  • Nguyen Thuy Chi, Quan Le Ha, 2023. Influences of drying methods o phycocyanin content and antioxidant activity of Spirulina. Science and Technology Journal of Agriculture and Rural development, Vietnam, Vol 2, June, 2023, 47-55.
  • Pham Thi Thu Hien, Cao Hai Yen, Pham Thi Hang Nga, Quan Le Ha, Dang Thi Thu, 2020. Angiotensin converting enzyme inhibitory and antibacterial activities of low molecular weight peptides derived from spent brewer’s yeast. Journal of Biotechnology 18(2): 331-340.
  • Ngo Minh Ngoc, Quan Le Ha (2017). Antioxidant activities of hydrolysates originated from soybean and soy milk residue. Vietnam Journal of science and technology, 55 (5A), 134-142.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha, Dinh Van Thuan, Dinh Van Thanh (2017). Influences of techological hydrolysis condition on nucleic acid content of spent brewer’s yeast hydrolysate. Vietnam journal of science and technology, 55 (5A), 169-177.
  • Nguyen Chinh Nghia, Nguyen Thi Thao, Pham Ngoc Hung, Nguyen Thi Ha, Nguyen Tien Thanh, Tran Thi Lan, Tran Hau Cuong, Quan Le Ha, Le Thanh Mai, Chu Ky Son (2017). High solid fermentation at pilot scale for potable ethanol production from rice. Vietnam journal of science and technology, 55 (5A), 177-185.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha (2016). Relationship between bitterness of brewer’s yeast hydrolysate and hydrophobiac aminoacid content. Journal of Science and Technology- Vietnam Academy of science and technology, Vol 54 (2C), 2016, pp 458-464.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha, Dinh Van Thuan (2016). Optimization for continuous overflow proteolytic hydrolysis of spent brewer’s yeast by using proteases. Journal of Biotechnology, 14 (4), 735-742.
Articles and Conferences
  • Ngo Minh Ngoc, Quan Le Ha (2017). Antioxidant activities of hydrolysates originated from soybean and soy milk residue. Vietnam Journal of science and technology, 55 (5A), 134-142.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha, Dinh Van Thuan, Dinh Van Thanh (2017). Influences of techological hydrolysis condition on nucleic acid content of spent brewer’s yeast hydrolysate. Vietnam journal of science and technology, 55 (5A), 169-177.
  • Nguyen Chinh Nghia, Nguyen Thi Thao, Pham Ngoc Hung, Nguyen Thi Ha, Nguyen Tien Thanh, Tran Thi Lan, Tran Hau Cuong, Quan Le Ha, Le Thanh Mai, Chu Ky Son (2017). High solid fermentation at pilot scale for potable ethanol production from rice. Vietnam journal of science and technology, 55 (5A), 177-185.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha (2016). Relationship between bitterness of brewer’s yeast hydrolysate and hydrophobiac aminoacid content. Journal of Science and Technology- Vietnam Academy of science and technology, Vol 54 (2C), 2016, pp 458-464.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha, Dinh Van Thuan (2016). Optimization for continuous overflow proteolytic hydrolysis of spent brewer’s yeast by using proteases. Journal of Biotechnology, 14 (4), 735-742.
  • Nguyen Thi Thanh Ngoc, Dinh Van Thuan, Dinh Van Thanh, Quan Le Ha (2016). Influence of factors on the bitterness and sensory taste in protein hydrolysate from spent brewer’s yeast. Journal of Science and Technology, Vol 54 ( 4A), 2016, pp 172-180.
  • Nguyen Thi Thanh Ngoc, Dinh Van Thuan, Dinh Van Thanh, Quan Le Ha (2016). Optimization for batch proteolytic hydrolysis of spent brewer’s yeast by using proteases. Journal of Science and Technology, Vol 54 (4A), 2016, pp 181-188.
  • Pham Thi Thu Hien, Dang Thi Thu, Lam Thi Hai Yen, Cao Hai Yen, Quan Le Ha (2016). Optimization of conditions for limited proteolytic hydrolysis of spent’s brewer’s yeast to produce low-weight molecular peptide with some bioactivities. Journal of Science and Technology, Vol 54 (4A), 2016, pp 259-266.
  • Nguyen Thi Thanh Ngoc, Quan Le Ha, Dinh Van Thuan, Dinh Van Thanh, 2015.  Study on factors influencing the degree of protein hydrolysis from spent brewer’s yeast. Journal of Science and Technology, Vol 53 (4B), 2015, pp126-135.
  • Quan Le Ha, Nguyen Ngọc Son, Nguyen Thi Thanh Ngoc. Extraction of beta-glucan from spent brewer’s yeast. Journal of Science and Technology, Vol 53 (4B), 2015, pp136-145.
  • Dang Thi Thu, Lam Thi Hai Yen, Dang Anh Quan, Pham Thi Thu Hien, Quan Le Ha, (2015). Study on conditions for limited proteolytic hydrolysis of spent brewer’s yeast to produce bioactive peptides. Journal of Biotechnology, Vol. 13 (2A), 2015, pp 651-656.
  • Nguyen Duc Tien, Quan Le Ha ( 2014). Purification of α-glucosidase inhibitor from Black beans (Vigna Cylindrica skeels) fermented by Aspergillus oryzae T6. Journal of Science and Technology, Vol 52 (5A), 2014, pp 343-349.
  • Quan Le Ha, Nguyen Duy Hoang (2013). Reasearch on using protease for obtaining protein hydrolysate from silkworm pupae. Vietnamese Journal of Science and Technology, vol 51 (6A), 2013, pp 270-276.
  • Nguyen Duc Tien, Hoang Dinh Hoa, Quan Le Ha (2013). Solid state fermentation of black beans with green kernel (Vigna cylindrica skeels) with Aspergillus oryzae for the food to support blood glucose control in type 2 diabetes, overweight and obesity. Science and Technology Journal of Agriculture and rural development. Ministry of agriculture and rural development, Vietnam, 2013, N 24, pp 59-64.
  • Duong Ngoc Quynh, Le Thanh Ha, Quan Le Ha (2013). Study on recovery of alpha glucosidase inhibitor from fermentation broth by Bacillus subtilis M1. J.of science and technology, J. of technical universities, Vietnam,  N93, 34-40
  • Phan Thi Hong Thao, Vu Thi Hanh Nguyen, Phi Quyet Tien, Quan Le Ha, Dang Tuyet Phuong, Le Gia Hy (2010). Research on selection capillary materials for immobilization of D-aminoacid oxidase applied in bio transformation. Journal of Chemistry, T-48 (4A ), pp 671-675.
  • Phan Thi Hong Thao, Vu Thi Hanh Nguyen, Quan Le Ha (2010). Research on biosynthesis of D-amino acid oxidase by yeast Trigonopsis varibialis. Journal of Biotechnology 8(3B), pp 1557-1563.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai, Quan Le Ha (2009). Determining optimal conditions for synthesis chitinase by Penicillium oxalicum. Journal of Science and technology, Technical universities, No 71, pp 74-78.
  • Khuat Huu Thanh, Quan Le Ha , Vu Manh Hao (2009). Study on several of solutions enhancing quality of black rice wine. Journal of Science and technology, Technical universities, No 71, pp 86-89.
  • Quan Le Ha, Vu Thi Phuong, Pham Thu Thuy (2008). Study on synthesis of beta-carotene from sugar cane molasses by filamentous fungal Blakeslea trispora in bioreactor. Journal of chemistry, Vol 46 (5A) 192-197.
  • Quan Le Ha, Le Ngoc Tu (1999).  Studies on use of mixed saccharifying enzymes for manufacture of beverage from black rice. Vietnamese Journal of Science and Technology, vol 37 (1), 1-5.
  • A. Jaquet, L. Quan, I.W. Marison, U.von.Stockar. (1999). Factors influencing the potential use of Aliquat 336 for the in situ extraction of carbocylic acids from cultures of Pseudomonas putida. Journal of Biotechnology, 68, 1999, 185-196.
  • Quan Le Ha, Hoang Dinh Hoa (1999). Selection of yeast for the beverages production from black rice. Vietnamese Journal of Agriculture and Food Industry, 8, 1999, 375-376.
  • Quan Le Ha. 1998.  Several factors influencing on the color of beverages produced from black rice. Vietnamese Journal of Science and Technology, vol 36 (3), 30-34.
  • Quan Le Ha, Le Ngoc Tu, Hoang Dinh Hoa (1994).  Studies on characteristics of amylase in rice malt produced in Vietnam. Vietnamese Journal of Science and Technology, vol 32 (6), 14-17.

Conference

  • Nguyen Van Khoi, Quan Le Ha, 2022. Study on hydrolysis conditions of oyster (Crassostrea gigas) by protese for obtaining hydrolysate with antioxidant activity. Proceedings of The National Biotechnology Conference 2022, November, 1321-1327.
  • Nguyen Thi Ngoc Hoi, Bui Thi Phuong Dung, Pham Phuong Thao, Quan Le Ha*. Antioxidative and anti-tyrosinase of Vietnamese commercial catfish (Pangasius Hypophthalmus) gelatin hydrolysate. Proceedings the 14th Asian biohydrogen biorefinery and bioprocess symposium-ABBS 2019 Innovation and Technology towards a sustainable bio-economy, 13-15 November, 2019, pp 99-102.
  • Nguyen Thi Thanh, Quan Le Ha*, (2018). Antioxidant activity of hydrolysed soybean and its application in sandwich processing. Proceedings of the 6th national symposium for research and development of natural products (RDNP 2018), ISBN 978-604-913-771-6, pp.56-64.
  • Mac The Vinh, Quan Le Ha, Nguyen Thanh Hang*, (2018). Study on application of Aspergillus oryzae, to hydrolyse protein from soymilk residue. Proceedings of the 6th national symposium for research and development of natural products (RDNP 2018), ISBN 978-604-913-771-6, pp.40-47.
  • Cao Thi Kim Chi, Quan Le Ha*, (2018). Several influencing factors on antioxidant activity of soymilk residue hydrolyzed by proteases. Proceedings of The national biotechnology conference 2018, ISBN  978-604-913-759-4.
  • Nguyen Thi Thanh Ngoc, Dinh Van Thuan, Dinh Van Thanh, Quan Le Ha (2017). Optimization for proteolytic hydrolysis spent brewer’s yeast by continuous circulation method. Proceedings of AFC the 15th Asean conference on Food science and technology, Vol.2, 14-17, November, 2017, 70-78
  • Quan Le Ha, Nguyen Nhu Ngoc (2016). Antagonistic microorganism Bacillus subtilis BKH against postharvest diseases of oranges during storage. Oral presentation 6th International Symposium for the Development of Integrated Pest Management (IPM) for sustainable agriculture in Asia and Africa 2016, Niigata University, Japan, 2-3 march, 2016.
  • Nguyen Hoang Ngoc Minh, Quan Le Ha (2015). Research on influences of physical factors on yield of polysaccharide extraction from ganoderma lucidum. Proceeding of Quality management and Food safety Conference (QMFS 2015), Hanoi, 10-11/11/2015. ISBN: 978-604-913-415-9, pp.119-128
  • Quan Le Ha, Le Thanh Ha, Nguyen Thu Hien (2013). Research on inhibitory activity against alpha-amylase of bean molded with Aspergillus oryzae. The 5th AUN/SEED-Net Regional Conference on Biotechnology, January 22nd-23rd, 2013.
  • Ha Le, Quynh Duong, Le Ha Quan (2013). Production of alpha -glucosidase inhibitor by Bacillus subtilis M1. The 5th AUN/SEED-Net Regional Conference on Biotechnology, January 22nd-23rd, 2013
  • Phan Thi Hong Thao, Dang Thi Thuy Duong, Phi Quyet Tien, Vu Thi Hanh Nguyen, Quan Le Ha, Le Gia Hy, (2013). Purification and properties of recombinant D-aminoacid oxidase from Trigonopsis Variabilis KCTC 0864. Proceedings National Biotechnology Conference 2013, 27 september, Ha Noi, pp 489-494.
  • Bui Thi Thanh, Quan Le Ha (2012). Using proteases to obtain Collagen chicken cartilage Hydrolysate containing angiotensin converting enzyme inhibitory activity. Proceeding of the 1st National scientific conference on biological research and teaching in Vietnam, Ha Noi, 12 December 2012, pp 690-697
  • Quan Le Ha, Le Thanh Ha và Nguyen Huy Hung (2011). Apha-glucosidase inhibitory activity of fermented products from several varieties bean by using Aspergillus oryzae, 5th International Symposium on Recent Advances in food analysis, Praha, November 1-4.
  • Nguyen Lan Huong, Quan Le Ha, Hoang Dinh Hoa (2010). Study on using microorganisms isolated from Vietnam traditional miso-like paste (tuong) for making product with fibrinolytic activity.2nd regional conferemce on biotechnology: Research and development on Food technology, Cambodia, February 11-12, 2010, pp 167-175.
  • Ha Le Thanh, Tuyet Vu Thi Anh, Le Ha Quan (2010). Screening of chitosanase producers and its application for Chitosan oligosaccharides productions. 2nd regional conference on biotechnology: Research and development on Food technology, Cambodia, February 11-12, 2010, pp 156-166.
  • Quan Le Ha, Nguyen Nhu Ngoc (2009). Study on some characteristics of antagonistic microorganism Bacillus subtilis BKH. Proceeding of National scientific conference on biotechnology, Thai nguyen, November, 2009, pp 563-566.
  • Lê Thanh Ha, Quan Le Ha, Nguyen thi Hoai Tram (2008). Study on proteolytic hydrolysis conditions of casein for Angiotensin converting enzyme inhibitory peptides (ACEIP). Proceedings of 4th National Scientific Conference on Biochemistry and Molecular Biology for Agriculture, Biology, Medicine and Food Industry, October, 15-17, 2008, 9-13.
  • Quan Le Ha, Nguyen lan Huong, Hoang Dinh Hoa (2008). Study on using protease of Aspergillus oryzae for making fermented soybean paste containing fibrinolytic enzyme. Proceedings of 4th National Scientific Conference on Biochemistry and Molecular Biology for Agriculture, Biology, Medicine and Food Industry, October, 15-17, 2008, 276-279.
  • Le Thanh Ha, Tran Thi Hanh, Quan Le Ha, Nguyen Thi Hoai Tram  (2007). Production of ACE inhibitors peptides by enzymatic hydrolysis of casein. Biohanoi 2007 From Bioscience to Biotechnology and Bioindustry.
  • Quan Le Ha (2007). Biological control of postharvest diseases of oranges using Bacillus subtilis BKH isolated from stored oranges. Biohanoi 2007 From Bioscience to Biotechnology and Bioindustry
  • Quan Le Ha, Vu Thi Phuong, Pham Thu Thuy (2006). Study on several factors influencing in synthesis of beta-carotene from sugar cane molasses by filamentous fungal Blakeslea trispora. Proceeding of the 20th scientific conference Hanoi University of Technology, 50-54.
  • Quan Le Ha, Dao Hong Diep, Pham Thu Thuy (2005). Study on using organic solvents for extraction of beta-carotene from Blakeslea trispora. Regional Symposium on chemical Engineering 2005. p. 341-345
  • Quan Le Ha, Pham Thi My Xuyen (2003) Isolation and selection of antagonistic microorganisms against postharvest diseases on mango. Proceedings of the 8th ASEAN Food Conference 2003, Hanoi, 419-423.
  • Quan Le Ha, Ngo Minh Ngoc (2003). Isolation and selection of antagonistic microorganisms against postharvest diseases on oranges. Proceedings of Vietnamese Conference of Biotechnology, Hanoi, 2003, pp 227-230.
  • Quan Le Ha, 2001. Research on production procedure of low-alcohol beer. Proceedings of Scientific works towards 45th anniversary of University establishment, HUST, 10/2001.
  • Quan Le Ha (1997). Determination of thermo-stability of spores Bacillus stearothermophillus. National workshop: Application of microorganisms in food technology and beverage, Hanoi, 10,1997.