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Assoc. Prof. Le Thanh Ha

Lecturer

Office: 208-C4

Phone: +84-24 3868 2453

Email: ha.lethanh@hust.edu.vn

Qualifications

  • 2005: PhD, Biotechnology, University of Halle, Germany
  • 1994: Master, Hanoi University of Technology, Vietnam
  • 1992: Engineer, Moscow Academy of Food Technology, Russia

Professional experience

  • 2012-present: Associate Professor of Department of Biotechnology, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam
  • 2008-2018: Head of Department of Biotechnology, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam.
  • 1992-1998 and 2005-2012: Lecturer of Department of Biotechnology, School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Vietnam
  • 1998-2005: Fellow researcher. University of Halle, Germany

Research interests

  • Exploiting microorganisms for shrimp waste treatment, for enzymes degrading chitin and lignocellulose, for improving fish sauce quality

Teaching responsibilities

  • BF2701: Introduction to Biotechnology
  • BF3713: Process and equipments in biotechnology
  • BF4709: Downstream processing
  • BF4506: Waste management in food industry
  • BF5160: Biotechnological production of organic acid and solvent

Projects

Principle Investigator

  • 2021-2022: Study on production of starter culture using halophile aroma-produced bacteria for applying in fish sauce fermentation of trashfish and derived protein from shrimp waste. Ministry of Education and Training.
  • 2017-2018: Isolation and selection of halophilic lactic acid bacteria Tetragenococcus sp. for using as starter culture to improve the aroma quality of short-term fermented fish sauce. Ministry of Education and Training.
  • 2014-2015: Research on procedure of recovery N-acetyl-D-glucosamine using chitinase and hexosaminidase, Ministry of Education and Training
  • 2009-2011: Application of microorganisms and enzymes for value added products from shrimp waste. Program of Biotechnology for Fisheries, Ministry of Agriculture and Rural development
  • 2008-2009: Production of chitooligosaccharides by chitosanase for pharmaceutical purpose, Ministry of Education and Training
  • 2008: Cloning CGTase from Bacillus macerans, Hanoi University of Science and Technology
  • 2007: Isolation and screening of chitosanase producer strains for chitooligosaccharides production, Hanoi University of Science and Technology

Participant

  • 2007-2008: Application of microorganisms and enzymes for Angiotensin Converting Enzyme Inhibitory Peptides- ACEIP from casein, Subproject of national project KC.04.05/06-10
  • 2011: Biotechnological exploring antimicrobial compound from by-products of fishery industry and their application on meat preservation
  • 2010-2011: Technology of recombinant chitinase and chitosanase production. Subproject of project of Ministry of Industry and Trade
  • 2012-2013: Research on using Aspergillus oryzae and Bacillus subtilis for obtaining bioactive compounds from fermented black bean for supporting diabetes patients. Ministry of Education and Training
  • 2012. Biotechnological exploitation of antimicrobial coumpounds from by-products of fishery factories for  meat preservation.  Ministry of Science and Technology.
  • 2016-2017. B2016-BKA-15  Application of enzyme and microorganisms for value added products from okara and their use in food processing. Ministry of Education and Training
  • 2016-2017. Production of food and animal feeds from by-products of shrimp processing industry. Ministry of Trade. Program of developments and application of biotechnology in processing industry till 2020.

Publications

Articles (recent 5 years)

  • To Thi Nga, Đang Xuan Tra, Le Thanh Ha. Isolation of halophilic lactic bacteria Tetragenococcus halophilus from Vietnamese fish sauce. Journal of Science and Technology  55(5A), 186-195, 2017.
  • Dang Thi Hương, Le Thanh Ha. Pretreatment for improving the yield of chitin hydrolysis by chitinase from Penicillium oxalicum 20B. Journal of Analytical Science 24 (4B), . tr. 79-85, 2019. ISSN-0868-3224,
  • Nguyen Thanh Hang, Nguyen Minh Thu, Nguyen Ngan Ha, Le Thanh Ha. Isolation, Screening and Identification of protease producing Bacteria from fish sauce. Journal of Science and Technology technical universities. 135, 64-69, 2019. ISSN-2354-1083
  • Le Thanh Ha, Nguyen Nam Trinh, Le Thi My Chau, Nguyen Thi Minh Tu – Characterization of Tetragenococcus halophilus from Vietnamese fish mash. Journal of Science and Technology  57(5), 544-550, 2019.
  • Le Thanh Ha, Le Duy Thang. OPTIMIZATION OF CONDITIONS FOR CAROTENOIDS EXTRACTION FROM SHRIMP WASTE USING ORGANIC SOLVENT. Journal of Science and Technology  3B (42-49), 2019.

Conferences (recent 5 years)

  • Quan Le Ha, Le Thanh Ha, Nguyen Thu Hien. Research on Inhibitory activity against a-amalase of bean molded with Aspergillus oryzae. The 5th AUN/SEED-net Regional Conference on Biotechnology. Biotechnology for Biorefinery. BPB 02, 2013.
  • Nguyen Phoung Nhue, Pham Thanh Huyen, Nguyen van Hieu, Le Thanh Ha, Phi Quyet Tien. Characterization of bacterium Bacillus amyloliquefaciens CH39 and its protease. National scientific conference of biotechnology 2013, 455-459.
  • Duong Thi Ngoc Quynh, Dong Thi Huong Tram, Le Thanh Ha. Production of N-acetyl-D-glucosamine from colloidal chitin by crude chitinase Penicillium oxalicum 20B. National scientific conference of biotechnology. 2013, 508-513.
  • Le Thanh Ha, Nguyen Thanh Tam, Nguyen Thi Thanh. Characterization of chitinase preparation from Penicillium oxalicum 20B obtained by ammonium sulfate precipitation. National scientific conference of biotechnology. 2018, 411-416
  • Dao Thi Thanh Xuan , Nguyen Tung Lam, To Thi Nga, Le Thanh Ha. Optimization of cultivation medium for CMCase production from Bacillus subtilis G4. PROCEEDINGS THE 14TH ASIAN BIOHYDROGEN BIOREFINERY AND BIOPROCESS SYMPOSIUM – ABBS 2019 INNOVATION AND TECHNOLOGY TOWARDS A SUSTAINABLE BIOECONOMY. BP13, Hanoi 2019, 110-115.
Articles and Conferences

Articles 

  • Le Thanh Ha. Effect of initial saccarose concentration, initial pH and inoculum size on fermentation of mulberry juice. Journal of Science and Technology. 1994 (5).
  • Sanden AM, Prytz I, Tubulekas I, Forberg C, Le H, Hektor A, Neubauer P, Pragai Z, Harwood C, Ward A, Picon A, De Mattos JT, Postma P, Farewell A, Nystrom T, Reeh S, Pedersen S, Larsson G. Limiting factors in Escherichia coli fed-batch production of recombinant proteins. Biotechnol Bioeng. 2003 Jan 20;81(2):158-66.
  • Lethanh H, Neubauer P, Hoffmann F. The small heat-shock proteins IbpA and IbpB reduce the stress load of recombinant Escherichia coli and delay degradation of inclusion bodies. : Microb Cell Fact. 2005 Feb 11;4(1):6.
  • Le Thanh H, Hoffmann F. Optimized production of active alpha-glucosidase by recombinant Escherichia coli. Evaluation of processes using in vivo reactivation from inclusion bodies. Biotechnol Prog. 2005 Jul-Aug;21(4):1053-61.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai, Quan Le Ha. Study on appopriate conditions for chitosanase biosynthesis by Penicillium oxalicum BKH2. Journal of Science and Technology technical universities. 2009 (71), 74-79.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai, Nguyen Thi Hong Diep.  Study on screening of chitosanase-producer strains for chitooligosaccharides production. Journal of Science and Technology technical universities. 2010 (78A), 1-7.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai. Optimization of the conditions for chitosan hydrolysis by Cellluclast 1.5L for chitooligosaccharides production. Journal of Science and Technology. 2010 (48), 359-366.
  • Do Thị Yen, Le Thanh Ha. Study on chitin recovery from shrimp shell using bromelin in pipeapple waste. Journal of Science and Technology. 2010 (48), 367-374
  • Le Thanh Ha, Ngo Thị Bich Ngoc, Nguyen La Anh. Extraction of chitin from shrimp waste by Lactobacillus plantarium NCDN4. Journal of Science and Technology, 49 (1A), tr 7-14, 2011.
  • Le Thanh Ha, Nguyen Thị Huyen Trang. Screening of protease producing Bacillus subtilis DT2 and its application for chitin extraction from shrimp waste. Journal of Science and Technology, 49 (1A), tr 302-308,  2011.
  • Quan Le Ha, Le Thanh Ha, La Quynh Nhu. Alpha-glucosidase inhibitory activity of fermented black bean by using Aspergillus oryzae. Journal of Science and Technology, 49 (1A), 58-64, 2011.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai. Effect of chitosan properties on its antimicrobial activity. Journal of Science and Technology, 49 (6A), 51-58, 2011.
  • Le Thanh Ha, Le Ngoc Hung, Ho Phu Ha. Optimization medium composition for chitisanase production from Penicillium oxalicum BKH2. Journal of Science and Technology, 49 (5B), 484-490, 2011.
  • Le Thanh Ha, Vu Thi Anh Tuyet. Effect of process parameters on chitosan hydrolysis by chitinase from Penicillium oxalicum BKH2. Journal of Science and Technology technical universities, Số 84, tr 141-146, 2012.
  • Le Thanh Ha, Do Thi Hoai Thu. Isolation of chitinase producer strains and conditions for chitinase production. Journal of Science and Technology technical universities, 87A, 36-41, 2012.
  • Ho Phu Ha, Nguyen Hai Yen, Le Thanh Ha. Antagonism towards E. coli of chitosan derived from shrimp waste using biological method. Journal of Science and Technology. 50 (3A), tr. 126-130, 2012.
  • Duong Ngoc Quynh, Le Thanh Ha, Quan Le Ha. Study on recovery of a-glucosidase inhibitor from fermentation broth by Bacillus subtilis M1. Journal of Science and Technology technical universities, 93A, 34-40, 2013.
  • Duong Thi Ngoc Quynh, Dang Thi Huong, Bui Thi Thuong, Le Thanh Ha. Effect of process parameters on chitinase và b-N-acetyl-D-glucosamine production by Penicillium oxalicum 20B. Journal of fisheries science and technology, Special issue, 2013.
  • Le Thanh Ha, Nguyen Thi Ha. Biotechnological process of chitin recovery from shrimp waste using Lactobacillus plantarum NCDN4. Journal of Vietnamese environment. Số 6 (3), 251-255, 2014.
  • Dang Thi Huong, Ha Quang Tung, Le Thanh Ha, Pham Thu Thuy. Effect of pretreatment on hydrolyzing chitin by chitinase from Penicillium oxalicum 20B for. N-acetyl-D-glucosamine production. Journal of Biotechnology, special issue 13(2A), 603 – 609, 2015.
  • Dang Thi Huong, Hoang Nư Le Quyen, Pham Thu Thuy, Le Thanh Ha. Characterization of chitinase fractions obtained by ultrafiltration of culture broth Penicillium oxalicum 20B. Journal of Biotechnology, special issue 13(2A), 611 – 617, 2015.
  • Hoang Nu Le Quyen, Mai Thanh Dat, Le Thanh Ha. Research on recovery and purification of N-acetyl-D-glucosamine produced from chitin by enzymatic method. Journal of Science and Technology 53(4B), 103-110, 2015.
  • Đặng Thi Hường, Phạm Thu Thủy, Lê Thanh Hà. Production of N-acetyl-D-glucosamine by crude chitinase preparation of Penicillium oxalicum 20B. Journal of Science and Technology technical universities 108, 125-129, 2015.
  • Dinh Van Bon, Dang Thi Xuan Tra, Le Thanh Ha. Improvement of chitinase biosynthesis by Penicillium oxalicum 20B for N-acetyl-D-glucosamine production. Journal of Science and Technology 53(4B), 118-125, 2015.
  • Dang Thi Huong, Le Thanh Ha, Pham Thu Thuy. Factors affecting the recovery yield and the purity of N-acetyl glucosamine from chitin hydrolysates. Journal of Science and Technology 54(4A), 23-30, 2016.
  • Hien Thi Nguyen, Xuan Thi Thanh Dao, Lang Thi Nguyen, Nga To Thi, Ha Thanh Le. Isolation, screening and the influence of cultivation factors on cellulase of bacteria isolated from termites gut. Journal of Science and Technology 54(4A), 89-96, 2016.
  • Dao Thi Thanh Xuan, Phi Quyet Tien, Le Thanh Ha. Characterization of cellulase preparation of Bacillus sp. G4 isolated from termites gut. Journal of Science and Technology 54(4A), 115-122, 2016.
  • Nguyen Hoang Anh, Nguyen Van Giang, Le Thanh Ha. Production of N-acetyl-Glucosamine from chitin using recombinant endochitinase and β-hexosamindase. Journal of Vietnam Argricutural Science and Technology 8, 109-114, 2017.
  • To Thi Nga, Đang Xuan Tra, Le Thanh Ha. Isolation of halophilic lactic bacteria Tetragenococcus halophilus from Vietnamese fish sauce. Journal of Science and Technology  55(5A), 186-195, 2017.
  • Dang Thi Hương, Le Thanh Ha. Pretreatment for improving the yield of chitin hydrolysis by chitinase from Penicillium oxalicum 20B. Journal of Analytical Science 24 (4B), . tr. 79-85, 2019. ISSN-0868-3224,
  • Nguyen Thanh Hang, Nguyen Minh Thu, Nguyen Ngan Ha, Le Thanh Ha. Isolation, Screening and Identification of protease producing Bacteria from fish sauce. Journal of Science and Technology technical universities. 135, 64-69, 2019. ISSN-2354-1083
  • Le Thanh Ha, Nguyen Nam Trinh, Le Thi My Chau, Nguyen Thi Minh Tu – Characterization of Tetragenococcus halophilus from Vietnamese fish mash. Journal of Science and Technology  57(5), 544-550, 2019.
  • Le Thanh Ha, Le Duy Thang. OPTIMIZATION OF CONDITIONS FOR CAROTENOIDS EXTRACTION FROM SHRIMP WASTE USING ORGANIC SOLVENT. Journal of Science and Technology  3B (42-49), 2019.

Conferences 

  • Le Thanh Ha. Production of active alpha-glucosidase by recombinant Escherichia coli in shake flask cultures. Proceeding of scientific conference on 50 anniversary of HUT. October 2006
  • Le Thanh Ha, Quan Le Ha, Nguyen Thi Hoai Tram. Production of ACE inhibitors peptides by enzymatic hydrolysis of casein. Biohanoi 2007. From Bioscience to Biotechnology and Bioindustry, 96
  • Le Thanh Ha, Quan Le Ha, Nguyen Thi Hoai Tram. Study on conditions of casein hydrolysis by enzyme for ACE inhibitors peptides. 4th National scientific conference of Biochemistry and Molecular biology for Agriculture, Biology, Medicine and Food Technology. 2008, 9-13.
  • Ha Le Thanh, Tuyet Vu Thi Anh, Le Ha Quan. Screening of chitosanase producers and its application for Chitosan oligosaccharides productions. 2nd regional conferemce on biotechnology: Research and development on Food technology, Cambodia, February 11-12, 2010, pp 156-166.
  • Le Thanh Ha, Nguyen Sy Thang, Pham Thu Thuy. Chitin hydrolysis by bromelain and chitinase for chitin olgosaccharides production. The 5th AUN/SEED-net Regional Conference on Biotechnology. Biotechnology for Biorefinery. BPB 03, 2013.
  • Le Thanh Ha, Duong Ngoc Quynh, Quan Le Ha. Production of a-glucosidase inhibitor by Bacillus subtilis M1. The 5th AUN/SEED-net Regional Conference on Biotechnology. Biotechnology for Biorefinery. BPB 09, 2013.
  • Quan Le Ha, Le Thanh Ha, Nguyen Thu Hien. Research on Inhibitory activity against a-amalase of bean molded with Aspergillus oryzae. The 5th AUN/SEED-net Regional Conference on Biotechnology. Biotechnology for Biorefinery. BPB 02, 2013.
  • Nguyen Phoung Nhue, Pham Thanh Huyen, Nguyen van Hieu, Le Thanh Ha, Phi Quyet Tien. Characterization of bacterium Bacillus amyloliquefaciens CH39 and its protease. National scientific conference of biotechnology 2013, 455-459.
  • Duong Thi Ngoc Quynh, Dong Thi Huong Tram, Le Thanh Ha. Production of N-acetyl-D-glucosamine from colloidal chitin by crude chitinase Penicillium oxalicum 20B. National scientific conference of biotechnology. 2013, 508-513.
  • Le Thanh Ha, Nguyen Thanh Tam, Nguyen Thi Thanh. Characterization of chitinase preparation from Penicillium oxalicum 20B obtained by ammonium sulfate precipitation. National scientific conference of biotechnology. 2018, 411-416
  • Dao Thi Thanh Xuan , Nguyen Tung Lam, To Thi Nga, Le Thanh Ha. Optimization of cultivation medium for CMCase production from Bacillus subtilis G4. PROCEEDINGS THE 14TH ASIAN BIOHYDROGEN BIOREFINERY AND BIOPROCESS SYMPOSIUM – ABBS 2019 INNOVATION AND TECHNOLOGY TOWARDS A SUSTAINABLE BIOECONOMY. BP13, Hanoi 2019, 110-115.